Eliminating Salmonella Typhi

The first priority for the Fondazione Achille Sclavo is to accelerate already-existing projects to eliminate diseases caused by Salmonellae, which primarily affect children.
In a very recent article in The Lancet John Maurice provocatively affirms that “Whoever invented the phrase ‘out of sight, out of mind’ must have been thinking of typhoid fever“. Once the years in which typhoid and paratyphoid fevers killed rich and poor alike in the big cities of industrialized countries ended, today only the poor, the poorest of the poor who live in the shanty towns in developing countries, are struck.  In a recent publication the Global Burden of Disease estimated about 14.3 million cases and 135.900 deaths caused by Salmonella Typhi and Paratyphi globally (Lancet Infect Dis 2019; 19:369-81). Overall, in 2017 typhoid and paratyphoid fevers were estimated to be responsible for 9.8 million  Disability-adjusted life years.

Salmonellosis is caused by a series of bacteria from the salmonella family: besides Salmonella Typhi, Salmonella Paratyphi and non-typhoid Salmonella both cause hundreds of thousands of deaths in the poorest areas of the world.

A CASE IN POINT: Typhoid Fever

“A first step in bringing typhoid fever out of the closet”
A recent expert meeting marks one of the first attempts to jolt governments into action against a disease
that is thriving largely unnoticed in many developing countries. John Maurice reports.

Reprinted with Permission from Elsevier (The Lancet, Volume 379, Issue 9817, Pages 699 – 700)


Another worrisome element which calls for an acceleration of the development of vaccines is that the treatments available to limit the extent of salmonella infections are losing their effectiveness due to the spread of antibiotic-resistant strains.


The first concrete objective of the Fondazione Achille Sclavo  is thus accelerating the development and affordable production of vaccine against salmonellae, which have already been identified and which

  • are already in preclinical or clinical studies,
  • have demonstrated effectiveness in children,
  • feature development technologies which have already been tested successfully,
  • may be produced at reduced costs.

This is our first goal: a world free of illnesses caused by salmonellae, thanks to three vaccines to be brought to fruition for poor countries within the next ten years.